FGSC #3162

Reporting Genes: T(II->I)NM177 leu-3 leu-4

Species: crassa

Allele: R156 R108

Alternate Strain Number: isolate R35a

Depositor: RLM

Linkage Group: II;I

Mating Type: a

Species Number: 10

ref1: Perkins & Barry Advances in Genetics 1977, https://doi.org/10.1016/s0065-2660(08)60246-1

Genes

Locus	Cultural Requirements	Link Group	Type
leu-3	IL. Right of the In(OY323) left breakpoint and nit-2 (12 to 18%). Left of cyt-1 (5 to 8%) and T(OY321) (57, 816, PB; D.D. Perkins, N.B. Raju, and E.G. Barry, in preparation). (868)Requires leucine (867, 868). Regulatory mutation; prevents synthesis of alpha-isopropylmalate isomerase and beta-isopropylmalate dehydrogenase and prevents full derepression of alpha-isopropylmalate synthetase; also involved in regulation of isoleucine and valine synthesis, q.v. (427, 771, 833) (Fig. 15). The original allele, 47313, is leaky, but some other alleles, e.g., R156, are not.	IL	B
leu-4	IL. Right of T(OY321); hence, of cyt-1. Left of cys-5(<<1%) (1125; D.D. Perkins, N.B. Raju, and E.G. Barry, in preparation). (429)Requires leucine, Structural gene for alpha-isopropylmalate synthetase (426, 427, 432) (Fig. 15). Feedback-negative mutants (426, 427). Hybrid synthetases with altered properties (432). Complementation between alleles (432, 1125).	IL	B
T(II->I)NM177	Translocation		B

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