FGSC #9066

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Reporting Genes: het-c^PA thr-2; vib-1

Species: crassa

Allele: PA - ; (1)

Alternate Strain Number: X80-49

Depositor: NLG

Mating Type: A

ref1: Xiang and Glass 2002 Genetics 162:89-101, https://doi.org/10.1093/genetics/162.1.89

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group
thr-2	IIL. Right of T(NM149) and ro-3 (6 to 25%). Left of T(AR179); hence, left of bal and arg-5 (3 to 18%). Adjoins thr-3 (< 0.1%) (808, 812, PB). Requires threonine. Cannot use other amino acids (1061). Lacks threonine synthetase (352) (Fig. 17). Strongly inhibited by methionine (320, 1061). Known alleles are not heat sensitive, unlike all known thr-3 alleles.	IIL
het-c^PA	Two alleles found in lab strains were originally called het-C and het-c. Following the discovery and demonstration of a third allele, het-c^PA, the symbol het-C was changed to het-c^OR and the symbol het-c was changed to het-c^EM. Three specificity types have been recognized and shown to be polymorphic in nature. These are designated het-c^OR, het-c^GR, and het-c^PA.
vib-1	Mutations in the vib-1 locus suppress growth inhibition and conidiation repression by genetic differences at het-c and mat and reduce HCD. The vib-1 locus encodes a nuclear localized putative transcriptional regulator. HET-C heterocomplex formation occurs in the vib-1 mutant, indicating that VIB-1 functions downstream of HET-C heterocomplex formation and may mediate some of the phenotypic responses to heterokaryon incompatibility at the transcriptional level.