FGSC #60

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Reporting Genes: fls al-1

Species: crassa

Allele: STL6 34508

Alternate Strain Number: 1249, ATCC 28602

Mutagen: UV

Depositor: DDP

Linkage Group: IR IR

Mating Type: a

Species Number: 10

Genetic Background: M

ref1: Perkins 1959 Genetics 44:1185-1208, https://www.genetics.org/content/44/6/1185.long

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
fls	IR. Between nit-1 (5 to 19%) and al-1 (6 to 19%) (P. St. Lawrence, cited in references 47, 789, or 812).Morphology of young cultures resembles that of fluffy; later conidiates. Suboptimal growth response to methionine (789). Called un(STL6).	IR	B
al-1	IR. Right of hom (<1%), arg-6 (<1 to 4%), T(T54M94), and al-2. Left of lys-3 (9%). (797, 808; D.D. Perkins, unpublished data). (482) Carotenoids abnormal. Strains carrying the various alleles differ widely in phenotype, ranging from white (e.g., 4637) and "aurescent" (pigment in peripheral conidia and conidiophores, 34508) to yellow mycelia and conidia (e.g., ALS4 and RES-25). See, for example, reference 1042. Strains carrying alleles ALS-14, RES-6, 34508, and RES-25 contain large amounts of phytoene (99 to 100% of the total neutral carotenoids), suggesting a lesion that affects phytoene dehydrogenase (398, 1039) (see Fig. 9). Strains carrying allele RWT-ylo accumulate zeta carotene and smaller amounts of neurosporene, suggesting a leaky block of the step between these intermediates (1071). It is not known whether phytoene dehydrogenase catalyzes the whole series of dehydrogenations or whether leakiness of this enzyme accounts for the different mutant phenotypes. For complementation tests, see references 500, 1039, and 1041. Fine-structure mapping (500, 1042). Translocation T(4637), inseparable from al-1, was the first albino mutation and one of the first chromosome rearrangements in Neurospora to be identified and studied (656). Allele 34508 called aur: aurescent.	IR	B