FGSC #7041

Reporting Genes: spe-2;aga

Species: crassa

Allele: JP100;UM906

Alternate Strain Number: IC-2568-1a

Mutagen: UV

Depositor: RHD

Linkage Group: VR;VIIR

Mating Type: a

Species Number: 10

Opposite Mating Type: 7044

ref1: Pitkin & Davis 1990. Arch Biochem Biophys 278:386, https://doi.org/10.1016/0003-9861(90)90275-4

Genes

Locus	Cultural Requirements	Link Group	Type
aga	VIIR. Between wc-1 (2%) and arg-10 (24 to 27%) (240, 697). Presumed structural gene for arginase (240, 697) (see Fig. 10). Unable to form ornithine from arginine; arginine is thus unable to satisfy the proline requirement of pro-3 in a pro-3 aga double mutant. Prototrophic single mutants develop polyamine requirement in the presence of arginine. This is due to feedback inhibition of ornithine biosynthesis by arginine, combined with a catabolic block in ornithine formation from arginine (240). Siderophore production is severely reduced in the absence of ornithine in the triple mutant aga arg-5 ota, which has been used to study iron transport (1146, 1147) and to obtain mutants defective in siderophore uptake (G.W. Charlang and N.P. Williams, personal communication); see sit.	VIIR	B
spe-2	responds to 1 mM spermidine, not to 1 mM putrescine	VR	B

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