FGSC #6427

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Reporting Genes: mus-25 nic-3

Species: crassa

Allele: FK123 Y31881

Alternate Strain Number: M2388

Depositor: EK

Linkage Group: VIIR L

Mating Type: a

Species Number: 10

Opposite Mating Type: 6426

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
mus-25	VIIC. Between met-7(4%, 6%) and un-10. Cloned. Epistasis group Uvs-6. Homologous to yeast RAD54, a gene involved in homologous recombination with sequence conserved from fungi to humans. Two alleles, SA3 and FK123. Both are highly sensitive to histidine, moderately sensitive to MMS, MNNG, and gamma rays, and not sensitive to UV or mitomycin C. At least FK123 is slightly sensitive to bleomycin. Homozygous barren.	VIIC	B
nic-3	VIIL. Right of spco-4 (1%) and do (3%). Left of thi-3 (9 to 27%) and csp-2 (16 to 22%) (539, 812, 816, PB). (M.K. Allen, cited in references 718 and 789) Uses nicotinic acid, nicotinamide, 3-hydroxyanthranilic acid, 3-hydroxykynurenine, or high concentrations of quinolinic acid (96, 1168). Accumulates alpha-N-acetylkynurenine; blocked in conversion of kynurenine to 3-hydroxykynurenine (1168) (Fig. 18). Pyridine nucleotide levels (111). Pathway from tryptophan to nicotinic mononucleotide, showing sites of gene action (96, 100, 368, 1168). The enzymatic reactions between 3-hydroxyanthranilate and nicotinic mononucleotide have not been demonstrated directly in Neurospora.	VIIL	B