FGSC #4179

Reporting Genes: uvs-6

Species: crassa

Allele: ALS35

Alternate Strain Number: M1193 a

Mutagen: UV

Depositor: EK

Linkage Group: IR

Mating Type: a

Species Number: 10

Genetic Background: SL6

Opposite Mating Type: 4178

ref1: Kafer 1983 Genetics 105:19-33, https://doi.org/10.1093/genetics/105.1.19; https://doi.org/10.4148/1941-4765.1645

ref2: Newmeyer et al 1978 Genetics 89:271, https://doi.org/10.1093/genetics/89.2.271

Genes

Locus	Cultural Requirements	Link Group	Type
uvs-6	IR. Between thi-1 (3 to 8%) and ad-9 (4%) (538; E. Kafer, personal communication; D. Newmeyer, unpublished data). Very close to met-6 (< 1%) (D. Newmeyer, unpublished data). (937). Increases sensitivity to UV (273, 937), ionizing radiation (537, 937, 940), nitrosoguanidine (509, 537), histidine (755), methyl methane sulfonate (536), ICR-170 and 4-nitroquinoline 1-oxide (509), and possibly mitomycin C (537). Normal UV-induced mutation (273). For mutation induction by other agents, see references 509 and 940. Increased spontaneous mutation not evident in the ad-3 system (275), but is found for recessive lethals in a heterokaryon test system (E. Kafer, personal communication). Normal dimer excision (1164). Defective in extracellular nuclease, giving reduced halos around colonies on DNA agar (538). Increased duplication instability due to mitotic recombination, deletion, or both (759). Homozygous barren (759), with a block at crozier differentiation (860). Reduced conidial viability (537). Switches to stop-start growth after initial normal growth (D. Newmeyer, unpublished data). Not completely recessive in heterokaryotic conidia (979). Increased stability of CPS (Pyr) activity in vitro suggests that protease activity may be reduced in the mutant uvs-6 (882); see also reference 360. Double mutant uvs-3;uvs-6 is inviable (506).	IR	B

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