FGSC #2530

Reporting Genes: T(I;VII)TM429 his-3

Species: crassa

Allele: TM429

Alternate Strain Number: 17-1077

Depositor: DDP

Linkage Group: I at hist-3;VII

Mating Type: A

Species Number: 10

Opposite Mating Type: 2531

ref1: Angel et al 1970. Austr J Biol Sci 23:1229-1240, https://doi.org/10.1071/bi9701229

ref2: Angel PhD thesis, Chap 7, https://doi.org/10.25911/5d6e4a0117331

Genes

Locus	Cultural Requirements	Link Group	Type
his-3	IR. Right of met-10 (R.L. Metzenberg, personal communication). Left of cog (1 to 3%) (172,174), ure-4 (1%) (78), and ad-3A (1%) (271). (434)Requires histidine (434). Complex gene coding for histidinol dehydrogenase, phosphoribosyladenosine 5'-triphosphate-pyrophosphohydrolase, and phosphoribosyl-adenosine 5'-monophosphate-cyclohydrolase (16, 673) (Fig. 14). All three activities appear to be catalyzed by a single protein (673). Strains carrying different individual alleles may lack only the early reaction(s) or only histidinol dehydrogenase, or both. Those that lack only histidinol dehydrogenase accumulate histidinol (16, 162, 1123). Mutants produce cross-reacting material (220). Used to study intralocus complementation and recombination (15, 16, 27, 162, 164, 171, 172, 1121, 1122, 1124). Intralocus recombination is regulated by cog and by rec-2 (27, 171); it is not affected by rec-1 (172). Translocation T(IR;VII)TM429, with one breakpoint in his-3, has been used to show that cog is cis-acting (171). Initial alleles: C140 and T1710 (= C1710).	IR	B
T(I;VII)TM429	Translocation		B

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