FGSC #2517

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Reporting Genes: csp-2 nic-3

Species: crassa

Allele: FS591 Y31881

Depositor: CPS

Linkage Group: VII VIIL

Mating Type: A

Species Number: 10

ref1: https://doi.org/10.1093/genetics/78.2.679

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
csp-2	VIIL. Linked to thi-3 (<1%), probably to the right. Left of T(T54M40) (972, PB). Conidia fail to separate and become airborne. Cultures on agar readily scored by the tap test. Resembles csp-1. Conidia are freed in water suspension long after induction of aerial growth and at only 1/100 the concentration of the wild type. A csp-1;csp-2double mutant releases no detectable free conidia under the same conditions (972). Most csp-2alleles complement csp-1 in forced heterokaryons to form the wild-type number of free conidia (972), but csp-2(UCLA102) does not (969). Conidiating colonies of the csp-2;sn cr-1 strain on replica plates can be overlayered without the conidia being spread (744); photograph (747).	VIIL	B
nic-3	VIIL. Right of spco-4 (1%) and do (3%). Left of thi-3 (9 to 27%) and csp-2 (16 to 22%) (539, 812, 816, PB). (M.K. Allen, cited in references 718 and 789) Uses nicotinic acid, nicotinamide, 3-hydroxyanthranilic acid, 3-hydroxykynurenine, or high concentrations of quinolinic acid (96, 1168). Accumulates alpha-N-acetylkynurenine; blocked in conversion of kynurenine to 3-hydroxykynurenine (1168) (Fig. 18). Pyridine nucleotide levels (111). Pathway from tryptophan to nicotinic mononucleotide, showing sites of gene action (96, 100, 368, 1168). The enzymatic reactions between 3-hydroxyanthranilate and nicotinic mononucleotide have not been demonstrated directly in Neurospora.	VIIL	B