FGSC #679

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Reporting Genes: ad-5

Species: crassa

Allele: Y112M192

Alternate Strain Number: 74A-Y12-M192

Mutagen: X

Depositor: MEC

Linkage Group: IL

Mating Type: A

Species Number: 10

Genetic Background: SL

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
ad-5	IL. Between phe-1 and arg-1 (1%) (816; H.B. Howe, Jr., personal communication). (482) Uses adenine or hypoxanthine (682) (Fig. 8). Accumulates AICAR (81, 904) and SAICAR (81). Some mutants are stimulated by histidine and may not grow on hypoxanthine unless histidine is present; others may be inhibited by histidine (393; M.E. Case, personal communication). Produces some purple pigment, but less than ad-3A and ad-3Bmutants (526). Called complementation group J. Evidence, apparently enzymatic, given in reference 120 suggests that some ad-5 mutants lack both AICAR formyltransferase and inosine 5'-monophosphate cyclohydrolase, but apparently other ad-5 mutants lack only the formyltransferase. Indirect evidence (902, 904) suggests that strains carrying ad-5 allele Y112M192 are blocked at the formyltransferase step.	IL	B