FGSC #393

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Reporting Genes: un-4 trp-2

Species: crassa

Allele: 66204(t) 75001

Alternate Strain Number: 66204,75001,

Depositor: MBM

Linkage Group: IVL;VIR

Mating Type: A

Species Number: 10

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
trp-2	VIR. Right of del (0 to 13%). Left of un-23 (5 to 27%), T(OY320), and ws-1 (38%) (818, 822, 1019, PB). Uses kynurenine, anthranilic acid, indole, or tryptophan (96). Kynurenine is utilized by conversion to anthranilate (447). Inferred to be the structural gene for the alpha subunit of the anthranilate synthetase complex (546). The gene product catalyzes anthranilate synthesis with ammonia but not with glutamine as the amino donor (29). Specifies anthranitate synthetase (glutamine linked) in collaboration with trp-1 in trifunctional trp-1+-trp-2+ enzyme aggregate (181, 259) (Fig. 11); see trp-1. Nonsense allele used to isolate supersuppressors (954) and to study enzyme complex restored by supersuppressors (183).	VIR	B
un-4	VIL. Right of lys-5 (2%). Left of T(T39M777) and cys-2(4%) (808, 1012). (482). Unknown function. Heat sensitive, 34°C versus 25°C (481). Formerly called un(66204).	VIL	B