FGSC #270

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Reporting Genes: Has been replaced by strain number: 1288

Species: crassa

Allele: 65108 34508

Alternate Strain Number: 1221

Depositor: DDP

Mating Type: a

Species Number: 10

ref1: https://www.genetics.org/content/44/6/1185.long

ref2: Dubes, G.R. 1953. Ph.D Thesis, Cal. Inst of Tech D138

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
al-1	IR. Right of hom (<1%), arg-6 (<1 to 4%), T(T54M94), and al-2. Left of lys-3 (9%). (797, 808; D.D. Perkins, unpublished data). (482) Carotenoids abnormal. Strains carrying the various alleles differ widely in phenotype, ranging from white (e.g., 4637) and "aurescent" (pigment in peripheral conidia and conidiophores, 34508) to yellow mycelia and conidia (e.g., ALS4 and RES-25). See, for example, reference 1042. Strains carrying alleles ALS-14, RES-6, 34508, and RES-25 contain large amounts of phytoene (99 to 100% of the total neutral carotenoids), suggesting a lesion that affects phytoene dehydrogenase (398, 1039) (see Fig. 9). Strains carrying allele RWT-ylo accumulate zeta carotene and smaller amounts of neurosporene, suggesting a leaky block of the step between these intermediates (1071). It is not known whether phytoene dehydrogenase catalyzes the whole series of dehydrogenations or whether leakiness of this enzyme accounts for the different mutant phenotypes. For complementation tests, see references 500, 1039, and 1041. Fine-structure mapping (500, 1042). Translocation T(4637), inseparable from al-1, was the first albino mutation and one of the first chromosome rearrangements in Neurospora to be identified and studied (656). Allele 34508 called aur: aurescent.	IR	B
mac	Used for met-6 allele 65108. See met-6. Probably allelic with met-6, q.v., but there are some differences between them. Requires methionine. Growth on methionine is stimulated by adenine with possible additional stimulation by cystine. Inhibited by guanine (290). One occurrence: allele 65108.		B