FGSC #9458

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Reporting Genes: mcb;fr

Species: crassa

Allele: RM110-9,B110

Alternate Strain Number: OG93

Depositor: OG

Linkage Group: VR,IL

Species Number: 10

Deposit Sheet ↗

Genes

Locus	Cultural Requirements	Link Group	Type
fr	IL. Between ro-10 (18%) and un-5 (6%) (798, PB). (789)Delicate branching on agar surface and delicate aerial growth with no conidia (789). Multiple hyphal branching (382). Deficient in glucose- 6-phosphate dehydrogenase (as are col-2 and balmutants) (949, 952). Partially deficient in linolenic acid (115); morphology partially corrected by exogenous linolenic acid (892, 943). Low adenylate cyclase activity and low adenosine 3',5'-phosphate (943, 950). Used to determine what functions are controlled by adenosine 3',5'-phosphate (779). Unlike cr-1, fr is not corrected morphologically by exogenous cyclic nucleotides (892, 951). Scott (943) reported that morphology is corrected by theophylline; Rosenberg and Pall (892) reported no correction by phosphodiesterase inhibitors. Cell wall analysis; photograph (112, 278, 946). Reduced amount of cell wall peptides (1165). Recessive in duplications (808). Female sterile. Both known alleles (B110 and R2499) revert to fr+.	IL	B
mcb	VR. Linked to al-3 (3%), cyh-2, sod-2. Encodes the regulatory subunit of cyclic AMP-dependent protein kinase. Has increased PKA activity. Consists of two overlapping transcriptional units. Discovered as a mutant allele extracted from a wild-collected strain. Cultures grown on agar are morphologically wild type at 25-30°C	VR	B