FGSC #7217 Mating Types: A Species: Neurospora crassa
Genotype: arg-10 nt
Alleles: B317 65001
Linkage Group(s): VIIR VIIR
Stock No. from Other Collection: 7011
Depositor of Strain: DDP
Strain of Opposite Mating Type: 0
Lesion: arg-10 arginine-10
Enzyme Name: arginosuccinate lyase
Lesion Information for Marker:
      Linkage Group of arg-10: VIIR
      Markers Left of arg-10: arg-11 1-2
      Markers Right ofarg-10: nt 1-12
Marker description or requirements:
      Uses arginine but not precursors.
Lesion: nt nicotinic acid or tryptophan
Enzyme Name: tryptophan pyrrolase
Lesion Information for Marker:
      Linkage Group of nt: VIIR
      Markers Left of nt: arg-10 (2 to 12%)
      Markers Right ofnt: sk (7 to 18%)
Marker description or requirements:
      VIIR. Between arg-10 (2 to 12%) and sk (7 to 18%) (789). (874) Uses nicotinic acid. May respond also to tryptophan, phenylalanine, tyrosine, quinic acid, and precursors of nicotinic acid or tryptophan, or both, depending on genetic background (448, 760). Best supplemented with nicotinamide and scored as a nic mutant. Probably deficient in tryptophan pyrrolase (tryptophan 2,3-dioxygenase) (Fig. 18), but direct evidence is lacking because tryptophan oxygenase cannot be assayed in Neurospora (368). Kynurenine formamidase levels are normal (368). Pyridine nucleotide levels (111).
Reference for: nt: 111. Brody, S. 1972. Regulation of pyridine nucleotide levels and ratios in Neurospora crassa. J. Biol. Chem. 247:6013-6017.
Reference for: nt: 368. Gaertner, F. H. 1981. A response to a letter from David Perkins concerning the question of whether nt mutants involve tryptophanpyrrolase. Neurospora Newsl. 28:12.
Reference for: nt: 448. Haskins, F. H. , and H. K. Mitchell. 1952. An example of the influence of modifying genes in Neurospora. Am. Nat. 86:231-238.
Reference for: nt: 760. Newmeyer, D. , and E. L. Tatum. 1953. Gene expression in Neurospora mutants requiring nicotinic acid or tryptophan. Am. J. Bot. 40:393-400.
Reference for: nt: 789. Perkins, D. D. 1959. New markers and multiple point linkage data in Neurospora. Genetics 44:1185-1208.
Reference for: nt: 874. Reisner, A. , R. W. Barratt, and D. Newmeyer. 1953. Confirmation of the seventh linkage group of Neurospora crassa. Genetics 38:685(Abstr. ).


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