FGSC #506 Mating Types: a Species: Neurospora crassa
Genotype: sfo
Alleles: E18829(d)
Linkage Group(s): VIIC
Genetic Background: M
Stock No. from Other Collection: 18558-5(24-7
Depositor of Strain: RWB
Strain of Opposite Mating Type: 576
Reference: MGB Emerson , Emerson #4 p 7-9 (1951) R42
Lesion: sfo sulfonamide dependent
Lesion Information for Marker:
      Linkage Group of sfo: VII
      Markers Left of sfo: thi-3 (6%)
      Markers Right ofsfo: hlp-1(1 to 9%);Linked to the centromere (<1%)
Marker description or requirements:
      Linked to the centromere (<1%) (318), between thi-3 (6%) (874) and hlp-1(1 to 9%) (458). Requires sulfonamide at 35°C and is stimulated by sulfonamide at lower temperatures (319). Overproduces p-aminobenzoic acid; hence, growth is inhibited by exogenous p-aminobenzoic acid (1179). For sfo;pab-1 double mutant on minimal medium plus sulfonamide, p-amino-benzoic acid is stimulatory at very low concentrations but inhibitory at higher (319). For sfo;met-1 double mutant on minimal medium plus sulfonamide, methionine is stimulatory at very low concentrations but inhibitory at higher (1180). Best tested on solid minimal medium growth tubes at 35°C. Suppressor mutations occur frequently (318).
Reference for: sfo: 318. Emerson, M. R. , and S. Emerson. 1951. The sulfonamiderequiring character (sfo) as a marker for chromosome VII of Neurospora crassa. Microb. Genet. Bull. 4:7-9.
Reference for: sfo: 319. Emerson, S. 1947. Growth responses of a sulfonamide-requiring mutant strain of Neurospora. J. Bacteriol. 54:195-207.
Reference for: sfo: 458. Ho, C. C. 1969. Mutants of Neurospora crassa permeable to histidinol. Genetics 62:725-733.
Reference for: sfo: 874. Reisner, A. , R. W. Barratt, and D. Newmeyer. 1953. Confirmation of the seventh linkage group of Neurospora crassa. Genetics 38:685(Abstr. ).
Reference for: sfo: 1179. Zalokar, M. 1948. The p-amino benzoic acid requirement of the "sulfonamide-requiring" mutant strain of Neurospora. Proc. Natl. Acad. Sci. U. S. A. 34:32-36.
Reference for: sfo: 1180. Zalokar, M. 1950. The sulfanomide-requiring mutant of Neurospora:threonine-methionine antagonism. J. Bacteriol. 60:191-203.


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