FGSC #261 Mating Types: a Species: Neurospora crassa
Genotype: ro-3;nic-3
Alleles: R2354 Y31881
Linkage Group(s): IIL;VIIL
Stock No. from Other Collection: 9075
Depositor of Strain: DDP
Strain of Opposite Mating Type: 260
Markers
Lesion: nic-3 nicotinic acid-3
Lesion Information for Marker:
      Linkage Group of nic-3: VIIL
      Markers Left of nic-3: spco-4 (1%) and do (3%)
      Markers Right ofnic-3: thi-3 (9 to 27%) and csp-2 (16 to 22%)
Marker description or requirements:
      VIIL. Right of spco-4 (1%) and do (3%). Left of thi-3 (9 to 27%) and csp-2 (16 to 22%) (539, 812, 816, PB). (M.K. Allen, cited in references 718 and 789) Uses nicotinic acid, nicotinamide, 3-hydroxyanthranilic acid, 3-hydroxykynurenine, or high concentrations of quinolinic acid (96, 1168). Accumulates alpha-N-acetylkynurenine; blocked in conversion of kynurenine to 3-hydroxykynurenine (1168) (Fig. 18). Pyridine nucleotide levels (111). Pathway from tryptophan to nicotinic mononucleotide, showing sites of gene action (96, 100, 368, 1168). The enzymatic reactions between 3-hydroxyanthranilate and nicotinic mononucleotide have not been demonstrated directly in Neurospora.
Reference for: nic-3: 96. Bonner, D. M. 1948. The identification of a natural precursor of nicotinic acid. Proc. Natl. Acad. Sci. U. S. A. 34:5-9.
Reference for: nic-3: 100. Bonner, D. M. , and C. Yanofsky. 1949. Quinolinic acid accumulation in the conversion of 3-hydroxyanthranilic acid to niacin inNeurospora. Proc. Natl. Acad. Sci. U. S. A. 35:576- 581.
Reference for: nic-3: 111. Brody, S. 1972. Regulation of pyridine nucleotide levels and ratios in Neurospora crassa. J. Biol. Chem. 247:6013-6017.
Reference for: nic-3: 368. Gaertner, F. H. 1981. A response to a letter from David Perkins concerning the question of whether nt mutants involve tryptophanpyrrolase. Neurospora Newsl. 28:12.
Reference for: nic-3: 539. Kafer, E. , and E. Perlmutter. 1980. Isolation and genetic analysis of MMS-sensitive mus mutants of Neurospora. Can. J. Genet. Cytol. 22:535-552.
Reference for: nic-3: 718. Murray, N. E. 1960. The distribution of methionine loci in Neurospora crassa. Heredity 15:199-206.
Reference for: nic-3: 789. Perkins, D. D. 1959. New markers and multiple point linkage data in Neurospora. Genetics 44:1185-1208.
Reference for: nic-3: 812. Perkins, D. D. , M. Glassey, and B. A. Bloom. 1962. New data on markers and rearrangements in Neurospora. Can. J. Genet. Cytol. 4:187-205.
Reference for: nic-3: 816. Perkins, D. D. , D. Newmeyer, C. W. Taylor, and D. C. Bennett. 1969. New markers and map sequences in Neurospora crassa, with adescription of mapping by duplication coverage, and of multiple translocation stocks for testing linkage. Genetica 40:247-278.
Reference for: nic-3: 1168. Yanofsky, C. , and D. M. Bonner. 1950. Evidence for the participation of kynurenine as a normal intermediate in the biosynthesis of niacinin Neurospora. Proc. Natl. Acad. Sci. U. S. A. 36:167-176.
Lesion: ro-3 ropy-3
Lesion Information for Marker:
      Linkage Group of ro-3: IIL
      Markers Left of ro-3: pyr-4 (1 to 2%)
      Markers Right ofro-3: T(NM149) and thr-2 (6 to 25%)
Marker description or requirements:
      IIL. Right of pyr-4 (1 to 2%). Left of T(NM149) and thr-2 (6 to 25%) (808, 812). Resembles ro-1 (812). Growth limited on glycerol medium (212). Called cflon map in reference 812.
Reference for: ro-3: 212. Courtright, J. B. 1975. Growth of ropy mutants on glycerol and acetate. Neurospora Newsl. 22:5.
Reference for: ro-3: 808. Perkins, D. D. , and E. G. Barry. 1977. The cytogenetics of Neurospora. Adv. Genet. 19:133-285.
Reference for: ro-3: 812. Perkins, D. D. , M. Glassey, and B. A. Bloom. 1962. New data on markers and rearrangements in Neurospora. Can. J. Genet. Cytol. 4:187-205.

 

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6/11/12