FGSC #9446 Species: Neurospora crassa
Genotype: spco-6;fr
Alleles: R2456,B110
Linkage Group(s): VIIL,IL
Stock No. from Other Collection: OG81
Depositor of Strain: OG
Lesion: fr frost
Enzyme Name: glucose-6-phosphate dehydrogenase
Lesion Information for Marker:
      Linkage Group of fr: IL
      Markers Left of fr: ro-10 (18%)
      Markers Right offr: un-5 (6%)
Marker description or requirements:
      IL. Between ro-10 (18%) and un-5 (6%) (798, PB). (789)Delicate branching on agar surface and delicate aerial growth with no conidia (789). Multiple hyphal branching (382). Deficient in glucose- 6-phosphate dehydrogenase (as are col-2 and balmutants) (949, 952). Partially deficient in linolenic acid (115); morphology partially corrected by exogenous linolenic acid (892, 943). Low adenylate cyclase activity and low adenosine 3',5'-phosphate (943, 950). Used to determine what functions are controlled by adenosine 3',5'-phosphate (779). Unlike cr-1, fr is not corrected morphologically by exogenous cyclic nucleotides (892, 951). Scott (943) reported that morphology is corrected by theophylline; Rosenberg and Pall (892) reported no correction by phosphodiesterase inhibitors. Cell wall analysis; photograph (112, 278, 946). Reduced amount of cell wall peptides (1165). Recessive in duplications (808). Female sterile. Both known alleles (B110 and R2499) revert to fr+.
Reference for: fr: 112. Brody, S. 1973. Metabolism, cell walls, and morphogenesis. In S. J. Coward (ed. ), Developmental regulation:aspects of celldifferentiation. Academic Press, New York.p. 107-154.
Reference for: fr: 115. Brody, S. and J. F. Nyc. 1970. Altered fatty acid distribution in mutants of N. crassa. J. Bacteriol. 104:780-786.
Reference for: fr: 278. De Terra, N. , and E. L. Tatum. 1963. A relationship between cell wall structure and colonial growth in Neurospora crassa. Am. J. Bot. 50:669-677.
Reference for: fr: 382. Garnjobst, L. , and E. L. Tatum. 1967. A survey of new morphological mutants in Neurospora crassa. Genetics 57:579-604.
Reference for: fr: 779. Pall, M. L. , J. M. Trevillyan, and N. Hinman. 1981. Deficient cyclic adenosine 3',5'-monophosphate control in mutants of two genes ofNeurospora crassa. Mol. Cell. Biol. 1:1-8.
Reference for: fr: 789. Perkins, D. D. 1959. New markers and multiple point linkage data in Neurospora. Genetics 44:1185-1208.
Reference for: fr: 798. Perkins, D. D. 1972. An insertional translocation in Neurospora that generates duplications heterozygous for mating type. Genetics 71:25-51.
Reference for: fr: 808. Perkins, D. D. , and E. G. Barry. 1977. The cytogenetics of Neurospora. Adv. Genet. 19:133-285.
Reference for: fr: 892. Rosenberg, G. , and M. L. Pall. 1979. Properties of two cyclic nucleotide-deficient mutants of Neurospora crassa. J. Bacteriol. 137:1140-1144.
Reference for: fr: 943. Scott, W. A. 1976. Adenosine 3':5'-cyclic monophosphate deficiency in Neurospora crassa. Proc. Natl. Acad. Sci. U. S. A. 73:2995-2999.
Reference for: fr: 946. Scott, W. A. 1979. Biochemical-genetic control of morphogenesis. In J. G. Scandalios (ed. ), Physiological genetics. AcademicPress, New York.p. 141-170.
Reference for: fr: 949. Scott, W. A. , and E. Mahoney. 1976. Defects of glucose 6-phosphate and 6-phosphogluconate dehydrogenases in Neurospora and theirpleiotropic effects. Curr. Top. Cell Regul. 10:205-236.
Reference for: fr: 950. Scott, W. A. , N. C. Mishra, and E. L. Tatum. 1974. Biochemical genetics of morphogenesis in Neurospora. Brookhaven Symp. Biol. 25:1-18.
Reference for: fr: 951. Scott, W. A. and B. Solomon. 1975. Adenosine 3',5'-cyclic monophosphate and morphology in Neurospora crassa:drug-inducedalterations. J. Bacteriol. 122:454-463.
Reference for: fr: 952. Scott, W. A. , and E. L. Tatum. 1970. Glucose-6-phosphate dehydrogenase and Neurospora morphology. Proc. Natl. Acad. Sci. U. S. A. 66:515-522.
Reference for: fr: 1165. Wrathall, C. R. , and E. L. Tatum. 1974. Hyphal wall peptides and colonial morphology in Neurospora crassa. Biochem. Genet. 12:59-68.
Lesion: spco-6 spreading colonial-6
Lesion Information for Marker:
      Linkage Group of spco-6: VII
      Markers Left of spco-6: Linked to do (10%), spco-5 (8%), and nt (20%)
Marker description or requirements:
      Linked to do (10%), spco-5 (8%), and nt (20%) (382). Complements col-17, col-2, spco-4, and spco-5 (382).
Reference for: spco-6: 382. Garnjobst, L. , and E. L. Tatum. 1967. A survey of new morphological mutants in Neurospora crassa. Genetics 57:579-604.


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