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2/3/10 The Broad Institute has released version 10 of the Neurospora crassa genome 1/6/10 Online registration for the Neurospora 2010 meeting is now available. Please visit the meeting homepage. 4/28/09
4/8/09 The proposed regulations are explicitely science based and define more clearly how an organism becomes subject to their review and emphasize the biology of the organism being genetically engineered. They specificy consider whether the organism causes injury to plants or whether it has been engineered to be more pathogenic to plants.
It is with great surprise and sadness that we have learned that
Professor Maruthi Mohan of Osmania University passed away January 6,
2009. 11/3/08 MICROBIOLOGY Special issue on fungal physiology Call for papers The field of fungal physiology is about to enter an unprecedented era. New genomics-based tools and resources are generating vast amounts of phenotypic data that reflect the effects of gene deletions on the physiology of the fungal cell. In addition, large-scale systems biology and metabolomic studies are now feasible and will also be yielding immense volumes of data. To highlight progress towards understanding the inner working of the fungal cell, Microbiology will publish a special issue in November 2009 devoted to fungal physiology. In addition to commissioned reviews, this issue will include original research manuscripts that focus on some aspect of fungal physiology. All manuscripts will be subject to normal peer review. Submissions are invited from mid-March 2009. The deadline for submissions is 1 June 2009. To register your interest in submitting a manuscript for this special issue, please send an email to the Organizing Editor, Dr Steven Harris (sharri1@unlnotes.unl.edu) or to the Editorial Office (micro@sgm.ac.uk). For further details about the journal, including Instructions for Authors, visit our website at: http://mic.sgmjournals.org
10/13/08
Ode to an Ectopic
Fungal Mutant (Pmk1-61)
Thy hyphae fair didst bloom upon my plate Note: During my Honours year I was endeavouring to clone the Stagonospora nodorum orthologue of the Magnaporthe grisea pathogenicity MAP kinase gene Pmk1 (Xu and Hamer, 1996) by degenerate PCR, followed by targeted gene disruption. It was demonstrated that the Mak2 gene was required for pathogenicity in S. nodorum (Solomon et al, 2005). During the screening of the transformants there was a number of in vitro phenotype exhibited. One of these was very pretty but ultimately turned out to be an ectopic insertion and was sent to the autoclave. When an Art in Science competition was announced, it presented an opportunity to redress a possible injustice!
7/2/08 We would like to provide an update on the status of Rowland Davis, a scientific leader and beloved member of the Neurospora community. About a month ago Rowland had a serious stroke at his home in Laguna Beach, California. He was in the intensive care unit of a nearby hospital for about two weeks and was then transferred to the acute care facility of Kindred Hospital in Westminster, California. His condition is now stable. It appears that he still has some paralysis and is not yet able to speak. His wife, Margot Norris, has asked those who wish to send messages to do so in the form of cards or letters. These can be sent to 3158 Bern Dr., Laguna Beach, CA 92651. Margot has been taking cards and letters and reading them to Rowland.
Job Postings3/1/10 Associate Professor in Below Ground Ecology The Department of Plant Biology at the University of Georgia invites applications for the Haines Family Professorship in Below Ground Ecology. This new position will focus on the below ground component of plant ecology: plant roots and their interactions with their environment, other plants and soil organisms (including fungi, bacteria and herbivores), and soil processes (including nutrient and water cycling). We seek an individual who addresses fundamental ecological and evolutionary questions and who integrates field- and lab-based research approaches with molecular tools and techniques. The successful candidate will have a Ph.D. degree and a record of scientific productivity appropriate for appointment at the level of associate professor. S/he is expected to continue and expand a vigorous externally-funded research program and to teach and train undergraduate and graduate students. The Plant Biology Department encompasses a broad range of disciplines and has historical strengths in plant ecology, evolutionary biology and mycology (http://www.plantbio.uga.edu). We interact with numerous other ecologists, mycologists, and plant scientists across campus in the Odum School of Ecology, Warnell School of Forestry and Natural Resources, Departments of Plant Pathology, Crop and Soil Sciences, Genetics, Biochemistry and Molecular Biology, and on-campus branch of the USFS Southern Research Station. There is also the potential to utilize a wide range of off-campus facilities such as the UGA Marine Institute at Sapelo Island and its associated Sapelo Island Microbial Observatory, the Coweeta Hydrologic Lab and LTER, and the Savannah River Ecology Lab. To apply, the following should be submitted at http://www.plantbio.uga.edu/positions.html : (1) a single PDF file containing a cover letter, curriculum vitae, and short statements of research interests and teaching philosophy; (2) a single PDF file containing three reprints of research papers; (3) four letters of recommendation submitted by references. The search will remain open until the position is filled. Complete applications (including letters) received by March 25, 2010 are assured full consideration. The Franklin College of Arts and Sciences, its many units, and the University of Georgia are committed to increasing the diversity of its faculty and students, and sustaining a work and learning environment that is inclusive. Women, minorities and people with disabilities are encouraged to apply. The University is an EEO/AA institution.
2/16/10 Assistant or Associate Professor, The University of
Nebraska-Lincoln The University of Nebraska-Lincoln is seeking candidates for a 9-month, tenure-leading, research, teaching and extension appointment in the Department of Food Science and Technology at the level of Assistant or Associate Professor. A Ph.D. in food science, microbiology, toxicology, or a closely related field is required. Strong commitments to research, teaching and extension; excellent communication skills; ability and desire to work cooperatively on multi-disciplinary projects; and knowledge of molecular microbiology or toxicology, molds, fungi and mycotoxins are required. Details of the position can be found at http://employment.unl.edu (requisition #100054).To be considered for this position, go to http://employment.unl.edu, access requisition #100054, complete the Faculty/Academic Administrative Information Form and attach a letter of application that includes a statement of your research interests, and your curriculum vitae. Review of applications will begin April 5, 2010 and continue until the position is filled.Additionally, three letters of reference should be sent directly to Dr. Milford Hanna, University of Nebraska – Lincoln, 211 Chase Hall, Lincoln, NE 68583-0726. These letters must arrive no later than April 5, 2010. The University of Nebraska has an active National Science Foundation ADVANCE gender equity program, and is committed to a pluralistic campus community through affirmative action, equal opportunity, work-life balance, and dual careers.
1/29/10 Assistant Professor, University of British Columbia Plant Cell/Molecular Biology The Department of Botany at the University of British Columbia invites applications for a tenure track Assistant Professor position available beginning July 1, 2010. We seek outstanding applicants who address fundamental research questions in plant or fungal biology using cellular, molecular, genetic, genomic and/or proteomic approaches in areas such as physiology, cell biology, biochemistry, signalling, epigenetics, and development. In addition to pursuing an internationally recognized research program, the successful candidate will be committed to excellence in the teaching of both undergraduate and graduate students. Applicants must have a PhD (or be near completion). Salary will be commensurate with experience. Responsibilities include establishing and conducting an internationally competitive, externally funded, research program, teaching at the undergraduate and graduate levels, supervising graduate students and performing service duties for the department, university, and academic/scientific community. Applicants should submit a single pdf file including a cover letter, curriculum vitae, research and teaching interests, and up to four publications to http://www.hr.ubc.ca/careers/faculty_postings.html. Evidence of teaching effectiveness would be an asset. In addition, three confidential reference letters should be sent as pdfs to jobs.botany@ubc.ca. Screening of applications will begin March 15, 2010. UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply; however, Canadians and permanent residents of Canada will be given priority.
1/6/10 Tenure Track Position/Tri-Cities Campus School of Molecular Biosciences
The
The successful candidate must have a Ph.D. in microbiology or in a closely related field at the time of hire. The successful candidate will be expected to teach at the undergraduate and graduate levels and should have a background that will allow broad participation in the teaching program. Expected research contributions in applied microbiology are summarized here. Candidates with emphasis in fungal biology are especially encouraged to apply. Interested candidates should send a letter of application, a complete curriculum vitae, and contact information for three references to bbates@tricity.wsu.edu or:
Applied Microbiology Search c/o Bonnie Bates
Consideration of applicants will begin January 29, 2010.
12/1/09 Two Post-Doctoral Positions to work in Molecular Biology and
Structural Molecular Biology 11/3/09 PhD studentship at the
Department of Translational Medicine, University of Manchester.
Co-funded by AlerGenetica SL. Topic: Characterization of fungal allergens associated with severe asthma Up to 20% of patients with severe asthma may be sensitized to allergens from common airborne fungal pathogens. Asthmatics sensitized to fungal allergens are more likely to be admitted to hospital or intensive care than those sensitized to non-fungal allergens alone. The term Severe Asthma with Fungal Sensitization (SAFS) has recently been proposed to describe this clinical entity. SAFS may be distinguished from the related condition, Allergic Broncho-Pulmonary Aspergillosois (ABPA): patients with ABPA may have asthma or cystic fibrosis, but have a higher IgE concentrations, suffer relapsing-remitting episodes of eosinophhilic pneumonia, can develop bronchial obstruction by Aspergillus fungal casts and develop a characteristic form of bronchiectasis. Fungal atopy-the presence of an IgE response to a fungus, is a hallmark of both conditions. In ABPA, the IgE response is to Aspergillus fumigatus, while in SAFS, the response is either to this organism or several other common environmental fungi. At present, high doses of corticosteroids are the mainstay of therapy, with all the attendant adverse consequences of this treatment. Immunological responses in both conditions are associated with an allergen-driven Th2 weighted T cell response. The induction of allergen-specific tolerance by therapeutic means has the potential to offer disease amelioration or possibly even cure. To do this, we need to know precisely which fungal allergens are associated with each of the above diseases (major allergens) so that tolerance to the relevant allergen can be studied. Each fungal species expresses a large number of fungal allergens. Preliminary studies have identified possible major allergens for a few common airborne environmental fungi, but few if any of these studies have included control sera or used well characterized patient cohorts with clearly-defined asthmatic or cystic fibrosis populations. The list of species for which preliminary studies exist is incomplete. This project will utilize the well-characterized patient cohorts based at the Respiratory Research Group in Wythenshawe Hospital a Univerity of Manchester affiliated hospital . Sera is already being collected from large cohorts for asthma, cystic fibrosis and ABPA. A variety of techniques will be used to define the panel of fungal allergens of relevance for each disease. In addition, the roles of IgG4-mediated tolerance to fungal allergens will be explored. The environmental exposure of individuals to candidate fungal allergens will be determined in a variety of settings. Finally, the candidate will
examine B cell responses to candidate fungal allergen T cell epitope-peptides.
This position is co-funded by the University of Manchester and
AlerGenetica SL a new Spanish biopharma company based at the Institute
of Technology, Canarias, based in Santa Cruz, Tenerife. The candidate
will be expected with interact with researchers at AlerGenetica and
spend six months at AlerGenetica. 11/3/09 Post-Doctoral Fellowship in Molecular Biology - Universidade de Sao Paulo, Brazil Working area: Molecular Biology Project title: Functional analysis of the transcription factor XlnR involved in regulation of transcription of cellulases- and hemicelullases-encoding genes in Aspergillus niger Field of knowledge: Biochemistry Principal investigator: Gustavo Henrique Goldman Unit/Instituition: Faculdade de Ciências Farmacêuticas de Ribeirão Preto/Universidade de São Paulo Summary: Candidate needs experience in Biochemistry and
Molecular Biology. The main aim of the project is to understand at
molecular level how the transcription factors XlnR and CreA induces and
represses, respectively, the transcription of cellulases- and
hemicellulases-encoding genes in the filamentous fungus Aspergillus
niger.
10/7/09 Multiple Faculty positions at all levels,
including the Chair of the Division of Cell Biology and Biophysics, are
available in the School of Biological Sciences, University of
Missouri-Kansas City. The positions were advertised in the 25 September 2009 issue of Science, and details can be found at: Professor and Head, Division of Cell Biology and Biophysics and Tenure Track Faculty Position in the Division of Molecular Biology and Biochemistry The FGSC is encouraging researchers in fungal genetics to apply for these positions. There is a growing core of researchers working on fungal genetics at UMKC and the administration supports our efforts to build on the recognized excellence of the FGSC to attract top researchers to UMKC. 10/6/09 Postdoctoral positions available with the Loros and Dunlap Labs at Dartmouth Medical School We have funds now in hand to support several postdocs working with us generally in the areas of circadian clock mechanism and output regulation in both mammalian cell culture and in Neurospora, light regulation in fungi, and/or Neurospora genomics. Please note that we are after the right people, not just bodies to work on pre-set projects. Because of this we have left the descriptions purposefully vague, and postdocs are not limited to work exclusively on Neurospora, or on specific proposals, although we (obviously) have many ideas for sure-fire projects. In addition to work on mammalian cell culture models and on the Neurospora clock and light responses, we have ongoing work in mathematical modeling and simulation, Saccharomyces, and are interested in pursuing work on circadian rhythms in other fungi including possibly Magnaporthe, Aspergillus sp. or Fusarium sp. if the right candidate appears. The genomics work will focus on Neurospora; we'll be engaged in high throughput (Solexa) sequencing and ChIP-SEQ in association with the NIGMS-funded ENCODE-like Program Project grant to map transcriptional responses on a genome-wide scale. Please go to http://dms.dartmouth.edu/dunlap/ for recent publications and an idea of what projects are being pursued. Candidates should be well versed in standard genetics and molecular biology, and come with strong recommendations. No expertise in rhythms or in fungi is expected. The need for a strong work ethic and excellent interpersonal skills goes without saying. Send letter of inquiry, including list of publications, and the names, addresses, phone numbers, and email addresses of three references to Jay Dunlap or to Jennifer Loros, Dept. Genetics, 7400 Remsen, Dartmouth Medical School, Hanover, NH 30755. Dartmouth is, of course, an Equal Opportunity Employer, and women and minorities are encouraged to apply. However, preference will generally be given to applicants from North America due to issues with travel to interviews.
9/1/09 FAPESP process: 08/58634-7 Summary: The Laboratory of Biochemistry and Molecular Biology
of Fungi, Faculty of Medicine of Ribeirão Preto-USP, has a vacancy for a
Postdoctoral Position to study the nutrient and ambient pH sensing in
fungi.
8/27/09 Post-Doctoral Research Associate: 7/17/09 Postdoctoral positions available at Washington University in Saint Louis Several positions are currently available in the laboratory of Tamara Doering to study Cryptococcus neoformans. The laboratory is located in a highly interactive, collegial, and well-regarded department of Molecular Microbiology on a medical school campus that is equipped with state of the art facilities. Washington University offers an outstanding academic environment and St. Louis is a great place to live. Work in the lab is focused on exciting aspects of cryptococcal polysaccharide capsule synthesis and host-pathogen interactions. Several positions involving biochemistry, genetics, and molecular and cell biology are open now. To learn more or apply, contact Tamara at doering@wustl.edu. For applications, please send a CV, contact information for references, and a statement of research interests and career goals. 7/10/09 Post-Doctoral opportunities at UC-Riverside Two NIH-funded Postdoctoral Research Positions are available to study functional genomics and heterotrimeric G protein signaling pathways in the model eukaryotic filamentous fungus Neurospora crassa. The first position will follow up on the successful high-throughput gene knockout project in Neurospora (Colot, et al., PNAS 103:10352-7, 2006) and will utilize genome-wide approaches, including gene deletions, proteomics and protein-protein interaction studies to investigate gene function. The second position will continue the long-standing heterotrimeric G protein signaling project in the laboratory (Li et al., Annu. Rev. Microbiol. 61:423-52, 2007). The project will be focused on identification of novel effectors and determination of the relative contributions of multiple G proteins and associated regulatory proteins to signaling networks in Neurospora. Applicants should have a Ph.D. degree in Biochemistry, Biology or a related discipline, have recombinant DNA experience and possess a good command of spoken and written English. Experience in microbiological techniques (particularly with filamentous fungi) and protein biochemistry is desirable. Send a curriculum vitae (including a list of publications) and the names of three references to Dr. Katherine A. Borkovich, Professor, Department of Plant Pathology and Microbiology, 900 University Avenue, University of California, Riverside, CA 92521. E-mail: Katherine.Borkovich@ucr.edu. FAX: (951) 827-4294. The University of California, Riverside is an Equal Opportunity Employer. Women and Minorities are encouraged to apply. 7/10/09 Postdoctoral research position (Department of Microbiology & Immunology, University of Texas Health Science Center at San Antonio) A postdoctoral position is available in the laboratory of Dr. David Kadosh at the University of Texas Health Science Center at San Antonio. Research will focus on mechanisms that determine Candida albicans morphology and virulence in response to host environmental cues (for additional details see Carlisle, et al. PNAS 106:599-604 (2009), Banerjee et al., MBC 19:1354-1365 (2008) and http://www.uthscsa.edu/micro/faculty/dk/dk.asp). Many opportunities are available for collaboration with both basic and clinical mycologists at the San Antonio Center for Medical Mycology (see http://www.sacmm.org/). This group represents one of the largest mycology centers in the U.S. and includes 15 laboratories working on a variety of topics in fungal pathogenesis. Individuals with previous experience in molecular biology (including transcriptional regulation and genomics), cell biology, genetics, protein chemistry or fungal pathogenesis are especially encouraged to apply. Please send a cover letter, CV, and contact information for three references to Melissa Olveda (olvedam@uthscsa.edu). All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.7/10/09 Advanced Postdoctoral (“Oberassistant”) Position Available at ETH Zurich: Evolutionary biology and ecology of plant pathogenic fungi. We seek applicants who have a PhD in Plant Pathology or a related science, including Mycology, Microbiology, Genetics, Biology, or Ecology. Applicants should have demonstrated an ability to work independently and to publish research in international, peer-reviewed journals. Applicants should have effective communication skills, both oral and written and be able to lead and coordinate a research team of 2-4 people. Applicants should have finished at least one postdoc and have knowledge in one or more of the following fields: population genetics, evolutionary ecology, genetic epidemiology, phylogeography, and bioinformatics. Women candidates are especially encouraged to apply. Experience with fungi is desirable, but not required. A good publication record is essential. The successful applicant will be granted a high degree of flexibility in research direction and approach. Applicants who have experience with plant pathogens, coalescent analyses of sequence data and bioinformatics will have an advantage. Our major areas of research are population genetics, evolutionary biology, evolutionary ecology, experimental evolution, and phylogeography. Our primary experimental organisms are the plant pathogenic fungi Mycosphaerella graminicola, Phaeosphaeria nodorum, Rhynchosporium secalis and Rhizoctonia solani. The position is renewable annually for up to six years. Our research focuses
on the evolutionary biology of plant pathogenic fungi. We have global
collections of 1000s of strains for all four of our model pathogens. A
significant number (12-20) of microsatellite markers have already been
developed for each fungus, as well as suites of sequence loci comprising
introns in housekeeping genes, known or suspected pathogenicity genes,
and anonymous sequences in both nuclear and mitochondrial genomes.
Genome sequences are available for all four fungi. The ETH and the Institute of Integrative Biology possess advanced infrastructure for data collection and analyses including the Genetic Diversity Center (http://www.gdc.ethz.ch/) and the Functional Genomics Center Zurich (http://www.fgcz.ethz.ch/) as well as large computer clusters (http://www.asgard.ethz.ch/). Zurich is consistently rated as one of the most livable cities in the world. The Plant Pathology Group (http://www.path.ethz.ch/) is currently composed of ~30 people from 12 countries, and English is the working language of the group. But knowledge of German or French is useful outside of the university.
Applications consisting of a CV, publication
list and statement of research interests, with names and contact
information for 3 references should be prepared as a single pdf file and
sent by email before 1 September 2009 to Prof. Bruce A. McDonald at
bruce.mcdonald@agrl.ethz.ch. The position could be filled beginning
1 January 2010 but will remain open until a suitable person has been
found. 7/10/09 PhD Student Position in Fungal Quantitative Genetics Department of Plant and Soil Sciences, University of Delaware, Newark, DE USA An opening is available in the Wisser laboratory to a Ph.D. seeking student interested in studying natural variation in fungal pathogenicity on maize. A Ph.D. seeking student is preferred with an M.S. degree or experience in plant pathology, plant breeding, plant biology, quantitative genetics, and/or population genetics or related fields of study. Students interested in pursuing an M.S. degree may be considered. Our group studies quantitative trait variation of disease resistance in maize. We are looking for a student to initiate the development of a parallel framework to study the genetic basis of variation in fungal pathogenesis. The research project involves the development of novel microbial populations and techniques for processing microorganisms, the development of experimental designs to assess phenotypic variation in pathogen aggressiveness and virulence, and the production of genomic resources to be integrated with phenotypic data. This project will integrate multiple fields of study including quantitative and population genetics, experimental design and statistics, molecular biology, bioinformatics, and plant pathology. For further details contact Randall J Wisser, Ph.D. Department:
http://ag.udel.edu/PLSC/ 7/7/09 Two graduate student or beginning Post-doc positions at Michigan State University Two NSF-funded Postdoctoral Research or Graduate Student positions available to study evolution of sexual development in perithecium-producing ascomycetes. One position is at Michigan State University with Dr. Frances Trail, the other is at Yale U. with Dr. Jeffrey Townsend. The positions will involve comparative transcriptomics and functional genomics, and candidates will gain experience in computational biology. Candidates should have a solid background through coursework and (preferably) lab experience in molecular biology. Experience with fungi will be considered a plus. Contact Dr. Frances Trail (trail@plantbiology.msu.edu) for more information. 7/6/09 Research Associate at Texas A&M University A Research Associate position is available. Applicants must go to http://tamujobs.tamu.edu and fill out an application. The NOV is 091002, Research Associate. The Research Associate's primary duties are: Responsible for maintaining and organizing a laboratory whose primary function is to characterize the growth and developmental phenotypes of Neurospora crassa mutants (Phenotype Laboratory). Overseeing the daily operations of the Phenotype Laboratory; Characterization of N. crassa mutants; Maintaining the N. crassa mutant strain collection; Ordering supplies and preparation of laboratory materials; Assisting faculty and Teaching Assistants in supervising undergraduate student research; Maintaining and collating records of experimental observations and putting these records into form for sharing with the research community. Other duties as required. Required Education and Experience: A Master's Degree in Life Sciences or baccalaureate degree and 3 years relevant experience. This work requires microbiology experience, preferably with fungi, experience in molecular biology and familiarity with computer applications including Microsoft Excel. The laboratory will be used for formal undergraduate research training so the Research Associate will be expected to actively assist faculty and graduate teaching assistants in training undergraduate students. Requires ability to multi-task and work cooperatively with others. Preferred Education and Experience A Ph.D. is desirable as are 3 years supervisory experience. Teaching experience in a laboratory setting preferred. 7/6/09
Postdoctoral
Research Associate on Role of Immune Defense in Aspergillosis
5/20/09 Postdoctoral Fellow 3/6/09 Multiple faculty positions at
Midwestern University
2/9/09 POSTDOC POSITION TO STUDY TELOMERE INSTABILITY IN MAGNAPORTHE ORYZAE Background to the project: We have found that Magnaporthe isolates from perennial ryegrass have highly unstable telomeres. This instability is associated with the presence in the telomeres of two retroelements, which we have named MoTERs. To date, we have shown that one of the MoTER elements is an active transposon that inserts specifically at telomeres. We have also found that not all telomere rearrangements are caused by transposon insertions, with some being due to truncation and others to insertion of other transposons into the MoTER elements. Telomere-targeted transposons have been reported in a handful of other organisms and are actively studied in Drososphila and Bombyx. M.oryzae offers a number of advantages over these two systems - most notably lower element copy numbers, strains that lack the elements, and facile gene KOs. As a result, the study of MoTER elements promises to yield insights into telomere-targeted transposition that cannot be gained so easily in the other organisms. Consequently, we expect our system to develop into one of the premier models for studying telomeric transposons. Finally, the project also touches on general telomere biology, and as such will provide a "filamentous fungal" perspective on this crucial chromosome maintenance system. Current research is focused on addressing the following questions: 1) What types of genetic rearrangements are responsible for the
frequent changes that we observe in telomeric restriction patterns? We
have developed efficient protocols for targeted cloning of specific
chromosome ends and have already characterized a number of newly-formed
telomeres. Please send application materials to: Mark L Farman The University of Kentucky is an equal opportunity employer.
Meeting Announcements Neurospora 2010
"Cellular
and Molecular Fungal Biology" Gordon Research Conference
IMC9: the Biology of Fungi
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